Skip Navigation


Biometrika Advance Access originally published online on May 10, 2007
Biometrika 2007 94(2):403; doi:10.1093/biomet/asm027
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
94/2/403    most recent
asm027v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wang, Y.
Right arrow Articles by Rabinowitz, D.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2007 Biometrika Trust

Articles

Nonparametric estimation of age-at-onset distributions from censored kin-cohort data

Yuanjia Wang

Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 W. 168th St., New York, New York 10032, U.S.A.

Lorraine N. Clark

Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10031, U.S.A.

Karen Marder

Department of Neurology and Psychiatry, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10031, U.S.A.

Daniel Rabinowitz

Department of Statistics, Columbia University, 1255 Amsterdam Ave., New York, New York 10027, U.S.A.

wang{at}stat.columbia.edu

lc654{at}columbia.edu

kmarder{at}sergievsky.cpmc.columbia.edu

dan{at}stat.columbia.edu

Received for publication 1 August 2005. Revision received 1 August 2006.
  Abstract

We present a nonparametric estimator of genotype-specific age-at-onset distributions from kin-cohort data. Standard error calculations are derived and the methodology is illustrated through an analysis of the influence of mutations of the Parkin gene on Parkinson's disease. Semiparametric efficiency considerations are briefly discussed.

Key Words: Family data • Genotype • Parkinson's disease • Parkin mutation • Proband • Relative • Survival analysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.