Skip Navigation

Biometrika 1988 75(2):325-333; doi:10.1093/biomet/75.2.325
© 1988 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by VENZON, D. J.
Right arrow Articles by MOOLGAVKAR, S. H.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Origin-invariant relative risk functions for case-control and survival studies

DAVID J. VENZON and SURESH H. MOOLGAVKAR

Fred Hutchinson Cancer Research Center 1124 Columbia Street, Seattle, Washington 98104, U.S.A.

Several parametric families of relative risk functions have been proposed as models for matched case-control and survival data. Some advantages accrue to those in which relative risks are invariant under arbitrary translations of the origin of the covariate space, such as in the reassignment of values to dichotomous factors. It is shown in this paper that the family proposed by Guerrero & Johnson, which includes the commonly-used exponential and linear relative risk functions, has the simplest form of this origin invariance property. A differential equation that general origin-invariant relative risk functions must satisfy is derived. The effect of covariate translations on the parameter space is also discussed.

Key Words: Cox regression • Matched case-control study • Relative risk model


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.