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Biometrika 2009 96(2):383-398; doi:10.1093/biomet/asp015
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© 2009 Biometrika Trust

Article

Nonparametric additive regression for repeatedly measured data

Raymond J. Carroll

Department of Statistics, Texas A&M University, College Station, Texas 77843, U.S.A. carroll{at}stat.tamu.edu

Arnab Maity

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, U.S.A. amaity{at}hsph.harvard.edu

Enno Mammen and Kyusang Yu

Department of Economics, University of Mannheim, L 7, 3-5, 68131 Mannheim, Germany emammen{at}rumms.uni-mannheim.de kyusangu{at}yahoo.co.kr

Received for publication 1 October 2007. Revision received 1 October 2008.

We develop an easily computed smooth backfitting algorithm for additive model fitting in repeated measures problems. Our methodology easily copes with various settings, such as when some covariates are the same over repeated response measurements. We allow for a working covariance matrix for the regression errors, showing that our method is most efficient when the correct covariance matrix is used. The component functions achieve the known asymptotic variance lower bound for the scalar argument case. Smooth backfitting also leads directly to design-independent biases in the local linear case. Simulations show our estimator has smaller variance than the usual kernel estimator. This is also illustrated by an example from nutritional epidemiology.

Key Words: Additive model • Generalized least square • Nonparametric regression • Repeated measure • Smooth backfitting



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This Article
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