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Biometrika 2003 90(1):43-52; doi:10.1093/biomet/90.1.43
© 2003 by Biometrika Trust
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Marginal nonparametric kernel regression accounting for within-subject correlation

Naisyin Wang1

1 Department of Statistics, Texas A&M University, College Station, Texas 77843-3143, U.S.Anwang{at}stat.tamu.edu

There has been substantial recent interest in non- and semiparametric methods for longitudinal or clustered data with dependence within clusters.It has been shown rather inexplicably that, when standard kernel smoothing methods are used in a natural way, higher efficiency is obtained by assuming independence than by using the true correlation structure. It is shown here that this result is a natural consequence of how standard kernel methods incorporate the within-subject correlation in the asymptotic setting considered, where the cluster sizes are fixed and the cluster number increases. In this paper, an alternative kernel smoothing method is proposed. Unlike the standard methods, the smallest variance of the new estimator is achieved when the true correlation is assumed. Asymptotically, the variance of the proposed method is uniformly smaller than that of the most efficient working independence approach. A small simulation study shows that significant improvement is obtained for finite samples.

Key Words: Asymptotic relative efficiency: Asymptotics; Bandwidth: Generalised estimating equation; Local linear estimator: Working covariance matrix; Working independence estimator


Received August 2001. Revised May 2002


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