Skip Navigation

Biometrika 2002 89(1):238-244; doi:10.1093/biomet/89.1.238
© 2002 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tsiatis, A. A.
Right arrow Articles by McNeney, B.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Miscellaneous

Multiple imputation methods for testing treatment differences in survival distributions with missing cause of failure

Anastasios A.Tsiatis1, Marie Davidian1 and Brad McNeney2

1 Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, U.S.Atsiatis{at}stat.ncsu.edu davidian{at}stat.ncsu.edu 2 Department of Mathematics and Statistics, Simon Fraser University, Burnaby, British Colombia VSA 1S6, Canada mcneney{at}stat.sfu.ca

We propose a method for comparing survival distributions when cause-of-failure information is missing for some individuals. We use multiple imputation to impute missing causes of failure, where the probability that a missing cause is that of interest may depend on auxiliary covariates, and combine log-rank statistics computed from several ‘completed’ datasets into a test statistic that achieves asymptotically the nominal level. Simulations demonstrate the relevance of the theory in finite samples.

Key Words: Competing risks; Log-rank test; Missing at random; Survival analysis

Received August 2000. Revised August 2001


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.