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Biometrika 2001 88(3):895-900; doi:10.1093/biomet/88.3.895
© 2001 by Biometrika Trust
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Miscellaneous

Unbiased estimation of secondary parameters following a sequential test

Aiyi Liu1 and W.J. Hall2

1 Biostatistics Unit, Lombardi Cancer Center S112, Georgetown University Medical Center, Washington, DC 20007, U.S.Aliua1{at}gunet.georgetown.edu 2 Department of Biostatistics, University of Rochester Medical Center, Rochester, New York 14642-8630, U.S.A.hall{at}bst.rochester.edu

We consider, within a Brownian motion framework, estimation of secondary parameters following a sequential test.Whitehead (1986b) proposed a method for reducing the bias of maximum likelihood estimators. In this paper we present unbiased estimators to eliminate the bias.

Key Words: Brownian motion; Clinical trial; Truncation-adaptation

Received June 1999. Revised September 2000


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