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Biometrika 1998 85(4):883-892; doi:10.1093/biomet/85.4.883
© 1998 by Biometrika Trust
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Variance-balanced change-over designs for dependent observations

R. J. MARTIN and J. A. ECCLESTON

Department of Mathematics and Statistics, University of Sheffield Sheffield S3 7RH, U.K.r.j.martin{at}sheffield.ac.uk
Department of Mathematics, University of Queensland Brisbane, Queensland 4072, Australiajae{at}maths.uq.edu.au

We show that variance-balanced change-over designs can be obtained from orthogonal arrays for many dependence structures. Some examples and design comparisons are given.

Key Words: Carry-over effect • Change-over design • Cross-over design • Dependent observations • Generalised least squares • Optimal design • Ordinary least squares • Orthogonal array • Repeated measurements design


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