Skip Navigation

Biometrika 1997 84(3):737-743; doi:10.1093/biomet/84.3.737
© 1997 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by TODD, S.
Right arrow Articles by WHITEHEAD, J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

MISCELLANEA

Confidence interval calculation for a sequential clinical trial of binary responses

SUSAN TODD and JOHN WHITEHEAD

The Medical & Pharmaceutical Statistics Research Unit, The University of Reading P.O. Box 240, Earley Gate, Reading, Berkshire RG6 6FN, U.K. e-mail: S.C.Todd{at}reading.ac.uk J.R.Whitehead{at}reading.ac.uk

Consider a sequential test applied to two streams of binary responses in a comparative clinical trial. After the completion of such a trial Woodroofe's (1992) technique for accurate confidence interval estimation for a treatment difference can be applied. In this paper the technique is extended to provide confidence intervals for the individual absolute success probabilities of the two treatments in the trial, for which no current methodology exists. Accuracy is explored by simulation of coverage probabilities and individual confidence limit probabilities. The simulations concern a triangular test and an O'Brien & Fleming test.

Key Words: Binary data • Clinical trial • Sequential analysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.