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Biometrika 1995 82(3):650-654; doi:10.1093/biomet/82.3.650
© 1995 by Biometrika Trust
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MISCELLANEA

P-values for group sequential testing

MYRON N. CHANG1, A. LAWRENCE GOULD2 and STEVEN M. SNAPINN2

1 Statistics Department, University of Florida Gainesville, Florida 32611, U.S.A.
2 Merck Research Laboratories, West Point Pennsylvania 19486, U.S.A.

Received for publication 1 October 1992. Revision received 1 January 1995.
  Abstract

Group sequential testing procedures are widely employed in long-term clinical trials. We discuss several methods for computing the P-value following a group sequential trial based on different outcome-space orderings. We use a criterion defined in this paper to compare these methods and point out interesting differences.

Key Words: Consistency • Locally most powerful test • Outcome space • Power function • Uniformly most powerful test


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