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Biometrika 1995 82(2):277-286; doi:10.1093/biomet/82.2.277
© 1995 by Biometrika Trust
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Extending a Bayesian analysis of the two-period crossover to accommodate missing data

ANDREW P. GRIEVE

Biometrics Department, Pfizer Central Research Ramsgate Road, Sandwich, Kent CT13 9NJ, U.K.

A procedure is developed for performing a Bayesian analysis of a simple two-period crossover design when some observations are missing in one, or both, treatment periods. The approach requires the numerical evaluation of a single integral to be performed for each posterior marginal distribution of interest. The relative efficiency of this approach to one in which patients with missing data are excluded is investigated.

Key Words: Bayesian analysis • Missing data • Two-period crossover


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