© 1994 by Biometrika Trust
Articles |
Proportional hazards tests and diagnostics based on weighted residuals
1 Division of Biostatistics, School of Public Health, University of Minnesota Minneapolis, Minnesota 55455, U.S.A.
2 Department of Health Science Research Mayo Clinic, Rochester, Minnesota 55905, U.S.A.
Received for publication 1 March 1993.
Revision received 1 January 1994.
 |
Abstract |
|---|
Nonproportional hazards can often be expressed by extending the Cox model to include time varying coefficients; e.g., for a single covariate, the hazard function for subject i is modelled as exp {β(t)Zi(t)}. A common example is a treatment effect that decreases with time. We show that the function βi(t) can be directly visualized by smoothing an appropriate residual plot. Also, many tests of proportional hazards, including those of Cox (1972), Gill & Schumacher (1987), Harrell (1986), Lin (1991), Moreau, O'Quigley & Mesbah (1985), Nagelkerke, Oosting & Hart (1984), O'Quigley & Pessione (1989), Schoenfeld (1980) and Wei (1984) are related to time-weighted score tests of the proportional hazards hypothesis, and can be visualized as a weighted least-squares line fitted to the residual plot.
Key Words: Cox model • Loess • Schoenfeld residuals • Weighted regression
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. L. Hughes, M. Wang, D. L. Page, R. Gray, L. J. Solin, N. E. Davidson, M. A. Lowen, J. N. Ingle, A. Recht, and W. C. Wood Local Excision Alone Without Irradiation for Ductal Carcinoma In Situ of the Breast: A Trial of the Eastern Cooperative Oncology Group J. Clin. Oncol., November 10, 2009; 27(32): 5319 - 5324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Compton, M. E. Kelley, C. E. Ramsay, M. Pringle, S. M. Goulding, M. L. Esterberg, T. Stewart, and E. F. Walker Association of Pre-Onset Cannabis, Alcohol, and Tobacco Use With Age at Onset of Prodrome and Age at Onset of Psychosis in First-Episode Patients Am J Psychiatry, November 1, 2009; 166(11): 1251 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M.E. Lintsen, D.D.M. Braat, J.D.F. Habbema, J.A.M. Kremer, and M.J.C. Eijkemans Can differences in IVF success rates between centres be explained by patient characteristics and sample size? Hum. Reprod., October 16, 2009; (2009) dep358v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lai, D. L. Hershman, T. Doan, and A. I. Neugut The timing of cranial radiation in elderly patients with newly diagnosed glioblastoma multiforme Neuro Oncology, October 15, 2009; (2009) nop004v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Turakhia, D. D. McManus, M. A. Whooley, and N. B. Schiller Increase in end-systolic volume after exercise independently predicts mortality in patients with coronary heart disease: data from the Heart and Soul Study Eur. Heart J., October 2, 2009; 30(20): 2478 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ishwaran, E. H. Blackstone, C. Apperson-Hansen, and T. W. Rice A novel approach to cancer staging: application to esophageal cancer Biostat., October 1, 2009; 10(4): 603 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Strong, C. W. Kahler, A. M. Leventhal, A. M. Abrantes, E. Lloyd-Richardson, R. Niaura, and R. A. Brown Impact of bupropion and cognitive-behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment Nicotine Tob Res, October 1, 2009; 11(10): 1142 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Peters, R. J. Rosychuk, L. Hendson, J. J. Cote, C. McPherson, and J. M. Tyebkhan Improvement of Short- and Long-Term Outcomes for Very Low Birth Weight Infants: Edmonton NIDCAP Trial Pediatrics, October 1, 2009; 124(4): 1009 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Nosyk, Y. C. MacNab, H. Sun, B. Fischer, D. C. Marsh, M. T. Schechter, and A. H. Anis Proportional Hazards Frailty Models for Recurrent Methadone Maintenance Treatment Am. J. Epidemiol., September 15, 2009; 170(6): 783 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pala, V. Krogh, F. Berrino, S. Sieri, S. Grioni, A. Tjonneland, A. Olsen, M. U. Jakobsen, K. Overvad, F. Clavel-Chapelon, et al. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort Am. J. Clinical Nutrition, September 1, 2009; 90(3): 602 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Oberg, S. Cnattingius, S. Sandin, P. Lichtenstein, and A. Iliadou Birth Weight-Breast Cancer Revisited: Is the Association Confounded by Familial Factors? Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2447 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Cicek, S. L. Slager, S. J. Achenbach, A. J. French, H. E. Blair, S. R. Fink, N. R. Foster, B. F. Kabat, K. C. Halling, J. M. Cunningham, et al. Functional and Clinical Significance of Variants Localized to 8q24 in Colon Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2492 - 2500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuper, L. Yang, S. Sandin, M. Lof, H.-O. Adami, and E. Weiderpass Prospective Study of Solar Exposure, Dietary Vitamin D Intake, and Risk of Breast Cancer among Middle-aged Women Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2558 - 2561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Argyropoulos, C.-C. H. Chang, L. Plantinga, N. Fink, N. Powe, and M. Unruh Considerations in the Statistical Analysis of Hemodialysis Patient Survival J. Am. Soc. Nephrol., September 1, 2009; 20(9): 2034 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Hombach, N. Merkle, J. Torzewski, J. M. Kraus, M. Kunze, O. Zimmermann, H. A. Kestler, and J. Wohrle Electrocardiographic and cardiac magnetic resonance imaging parameters as predictors of a worse outcome in patients with idiopathic dilated cardiomyopathy Eur. Heart J., August 2, 2009; 30(16): 2011 - 2018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Zighelboim, A. P. Schmidt, F. Gao, P. H. Thaker, M. A. Powell, J. S. Rader, R. K. Gibb, D. G. Mutch, and P. J. Goodfellow ATR Mutation in Endometrioid Endometrial Cancer Is Associated With Poor Clinical Outcomes J. Clin. Oncol., July 1, 2009; 27(19): 3091 - 3096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yamamoto, I. Chervoneva, K. L. Sullivan, D. J. Eschelman, C. F. Gonsalves, M. J. Mastrangelo, D. Berd, J. A. Shields, C. L. Shields, M. Terai, et al. High-Dose Immunoembolization: Survival Benefit in Patients with Hepatic Metastases from Uveal Melanoma Radiology, July 1, 2009; 252(1): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Colleoni, V. Bagnardi, N. Rotmensz, S. Dellapasqua, G. Viale, G. Pruneri, P. Veronesi, R. Torrisi, A. Luini, M. Intra, et al. A risk score to predict disease-free survival in patients not achieving a pathological complete remission after preoperative chemotherapy for breast cancer Ann. Onc., July 1, 2009; 20(7): 1178 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-H. Groop, M. C. Thomas, J. L. Moran, J. Waden, L. M. Thorn, V.-P. Makinen, M. Rosengard-Barlund, M. Saraheimo, K. Hietala, O. Heikkila, et al. The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes Diabetes, July 1, 2009; 58(7): 1651 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. U. Cheang, S. K. Chia, D. Voduc, D. Gao, S. Leung, J. Snider, M. Watson, S. Davies, P. S. Bernard, J. S. Parker, et al. Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer J Natl Cancer Inst, May 20, 2009; 101(10): 736 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Winchester, T. V. Macfarlane, M. Thomas, and D. Price Antibiotic Prescribing and Outcomes of Lower Respiratory Tract Infection in UK Primary Care Chest, May 1, 2009; 135(5): 1163 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Ezell and E. E. Tanner-Smith Examining the Role of Lifestyle and Criminal History Variables on the Risk of Homicide Victimization Homicide Studies, May 1, 2009; 13(2): 144 - 173. [Abstract] [PDF]
|
|
|
|
|
|
T. J Key, P. N Appleby, E. A Spencer, R. C Travis, A. W Roddam, and N. E Allen Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1620S - 1626S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J Key, P. N Appleby, E. A Spencer, R. C Travis, A. W Roddam, and N. E Allen Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1613S - 1619S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Filardo, C. Hamilton, R. F. Hebeler Jr, B. Hamman, and P. Grayburn New-Onset Postoperative Atrial Fibrillation After Isolated Coronary Artery Bypass Graft Surgery and Long-Term Survival Circ Cardiovasc Qual Outcomes, May 1, 2009; 2(3): 164 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jiao, D. T. Silverman, C. Schairer, A. C. M. Thiebaut, A. R. Hollenbeck, M. F. Leitzmann, A. Schatzkin, and R. Z. Stolzenberg-Solomon Alcohol Use and Risk of Pancreatic Cancer: The NIH-AARP Diet and Health Study Am. J. Epidemiol., May 1, 2009; 169(9): 1043 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kitahata, S. J. Gange, A. G. Abraham, B. Merriman, M. S. Saag, A. C. Justice, R. S. Hogg, S. G. Deeks, J. J. Eron, J. T. Brooks, et al. Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival N. Engl. J. Med., April 30, 2009; 360(18): 1815 - 1826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. T. Eriksen, M. Sorensen, J. K. McLaughlin, L. Lipworth, A. Tjonneland, K. Overvad, and O. Raaschou-Nielsen Perfluorooctanoate and Perfluorooctanesulfonate Plasma Levels and Risk of Cancer in the General Danish Population J Natl Cancer Inst, April 15, 2009; 101(8): 605 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Oakes, T. J. Badger, E. G. Kholmovski, N. Akoum, N. S. Burgon, E. N. Fish, J. J.E. Blauer, S. N. Rao, E. V.R. DiBella, N. M. Segerson, et al. Detection and Quantification of Left Atrial Structural Remodeling With Delayed-Enhancement Magnetic Resonance Imaging in Patients With Atrial Fibrillation Circulation, April 7, 2009; 119(13): 1758 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sibbing, J. Stegherr, W. Latz, W. Koch, J. Mehilli, K. Dorrler, T. Morath, A. Schomig, A. Kastrati, and N. von Beckerath Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention Eur. Heart J., April 2, 2009; 30(8): 916 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bruno, M. Rotta, F. Patriarca, D. Mattei, B. Allione, F. Carnevale-Schianca, R. Sorasio, A. Rambaldi, M. Casini, M. Parma, et al. Nonmyeloablative allografting for newly diagnosed multiple myeloma: the experience of the Gruppo Italiano Trapianti di Midollo Blood, April 2, 2009; 113(14): 3375 - 3382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Basili, F. Lagona, P. Roberti di Sarsina, C. Basili, and T. Valeria Paterna Allopathic Versus Homeopathic Strategies and the Recurrence of Prescriptions: Results from a Pharmacoeconomic Study in Italy Evid. Based Complement. Altern. Med., April 1, 2009; (2009) nep023v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cervantes, B. Dupriez, A. Pereira, F. Passamonti, J. T. Reilly, E. Morra, A. M. Vannucchi, R. A. Mesa, J.-L. Demory, G. Barosi, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment Blood, March 26, 2009; 113(13): 2895 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Cotton, S. Peterson, P. A. Norkool, J. Takashima, Y. Grigoriev, D. M. Green, and N. E. Breslow Early and Late Mortality After Diagnosis of Wilms Tumor J. Clin. Oncol., March 10, 2009; 27(8): 1304 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Wallace, T. M. Morgan, T. F. Walsh, E. Dall'Armellina, W. Ntim, C. A. Hamilton, and W. G. Hundley Dobutamine cardiac magnetic resonance results predict cardiac prognosis in women with known or suspected ischemic heart disease. J. Am. Coll. Cardiol. Img., March 1, 2009; 2(3): 299 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Larfors, P. C. Lambert, M. Lambe, A. Ekbom, and S. Cnattingius Placental Weight and Breast Cancer Survival in Young Women Cancer Epidemiol. Biomarkers Prev., March 1, 2009; 18(3): 777 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Chlebowski, L. H. Kuller, R. L. Prentice, M. L. Stefanick, J. E. Manson, M. Gass, A. K. Aragaki, J. K. Ockene, D. S. Lane, G. E. Sarto, et al. Breast Cancer after Use of Estrogen plus Progestin in Postmenopausal Women N. Engl. J. Med., February 5, 2009; 360(6): 573 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Margulis, Y. Lotan, P. I. Karakiewicz, Y. Fradet, R. Ashfaq, U. Capitanio, F. Montorsi, P. J. Bastian, M. E. Nielsen, S. C. Muller, et al. Multi-Institutional Validation of the Predictive Value of Ki-67 Labeling Index in Patients With Urinary Bladder Cancer J Natl Cancer Inst, January 21, 2009; 101(2): 114 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Blum, T. Koyama, A. E. M'Koma, J. M. Iturregui, M. Martinez-Ferrer, C. Uwamariya, J. A. Smith Jr., P. E. Clark, and N. A. Bhowmick Chemokine Markers Predict Biochemical Recurrence of Prostate Cancer following Prostatectomy Clin. Cancer Res., December 1, 2008; 14(23): 7790 - 7797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sieri, V. Krogh, P. Ferrari, F. Berrino, V. Pala, A. C. Thiebaut, A. Tjonneland, A. Olsen, K. Overvad, M. U. Jakobsen, et al. Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1304 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Quackenbush and J. F. Venteicher Settlements, Outcomes, and the Recurrence of Conflict Journal of Peace Research, November 1, 2008; 45(6): 723 - 742. [Abstract] [PDF]
|
|
|
|
 |
|
 M. T. Goodman, Y. B. Shvetsov, K. McDuffie, L. R. Wilkens, X. Zhu, P. J. Thompson, L. Ning, J. Killeen, L. Kamemoto, and B. Y. Hernandez Prevalence, Acquisition, and Clearance of Cervical Human Papillomavirus Infection among Women with Normal Cytology: Hawaii Human Papillomavirus Cohort Study Cancer Res., November 1, 2008; 68(21): 8813 - 8824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Wiesbauer, G. Heinze, C. Mitterbauer, F. Harnoncourt, W. H. Horl, and R. Oberbauer Statin Use Is Associated with Prolonged Survival of Renal Transplant Recipients J. Am. Soc. Nephrol., November 1, 2008; 19(11): 2211 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Pellegrini, K. Lee, J. E. Olgin, M. P. Turakhia, Z. H. Tseng, R. Lee, N. Badhwar, B. Lee, and P. D. Varosy Impact of advanced age on survival in patients with implantable cardioverter defibrillators Europace, November 1, 2008; 10(11): 1296 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Locke, D. S. Warren, F. Dominici, A. M. Cameron, M. S. Leffell, D. A. McRann, J. K. Melancon, D. L. Segev, C. E. Simpkins, A. L. Singer, et al. Donor Ethnicity Influences Outcomes following Deceased-Donor Kidney Transplantation in Black Recipients J. Am. Soc. Nephrol., October 1, 2008; 19(10): 2011 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, I. Ruczinski, T. J. Jorgensen, G. Yenokyan, Y. Yao, R. Alani, N. J. Liegeois, S. C. Hoffman, J. Hoffman-Bolton, P. T. Strickland, et al. Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy J Natl Cancer Inst, September 3, 2008; 100(17): 1215 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cnattingius, S. Eloranta, H.-O. Adami, O. Axelsson, P. W. Dickman, C.-c. Hsieh, L. A. Mucci, D. Trichopoulos, M. Lambe, and A. L.V. Johansson Placental Weight and Risk of Invasive Epithelial Ovarian Cancer with an Early Age of Onset Cancer Epidemiol. Biomarkers Prev., September 1, 2008; 17(9): 2344 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pande, C. I. Amos, D. R. Osterwisch, J. Chen, P. M. Lynch, R. Broaddus, and M. L. Frazier Genetic Variation in Genes for the Xenobiotic-Metabolizing Enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and Susceptibility to Colorectal Cancer in Lynch Syndrome Cancer Epidemiol. Biomarkers Prev., September 1, 2008; 17(9): 2393 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Austin, K. G. Oldroyd, A. McConnachie, R. Slack, H. Eteiba, A. D. Flapan, K. P. Jennings, R. J. Northcote, A. C.H. Pell, I. R. Starkey, et al. Drug-Eluting Stents Versus Bare-Metal Stents for Off-Label Indications: A Propensity Score-Matched Outcome Study Circ Cardiovasc Interv, August 1, 2008; 1(1): 45 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bhaskaran, O. Hamouda, M. Sannes, F. Boufassa, A. M. Johnson, P. C. Lambert, K. Porter, and for the CASCADE Collaboration Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population JAMA, July 2, 2008; 300(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Daggett, S. D. Camp, O. Kwon, S. P. Rosenmerkel, and J. Klein-Saffran Faith-Based Correctional Programming in Federal Prisons: Factors Affecting Program Completion Criminal Justice and Behavior, July 1, 2008; 35(7): 848 - 862. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Roberts, P. M. Srivastava, N. Macmillan, D. L. Hare, S. Ratnaike, K. Sikaris, and F. L. Ierino B-type Natriuretic Peptides Strongly Predict Mortality in Patients Who Are Treated with Long-Term Dialysis Clin. J. Am. Soc. Nephrol., July 1, 2008; 3(4): 1057 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Christopherson, K. E. James, M. Tableman, P. Marshall, and F. E. Johnson Long-Term Survival After Colon Cancer Surgery: A Variation Associated with Choice of Anesthesia Anesth. Analg., July 1, 2008; 107(1): 325 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ali, Y. Abu-Omar, A. Patel, Z. Ali, A. Y. Sheikh, A. Akhtar, A. Pavlovic, P. Theodorou, T. Athanasiou, and J. Pepper Valve failure following homograft aortic valve replacement: does implantation technique have an effect? Eur. Heart J., June 1, 2008; 29(11): 1454 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bonassi, H. Norppa, M. Ceppi, U. Stromberg, R. Vermeulen, A. Znaor, A. Cebulska-Wasilewska, E. Fabianova, A. Fucic, S. Gundy, et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries Carcinogenesis, June 1, 2008; 29(6): 1178 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Thabut, P. Ravaud, J. D. Christie, Y. Castier, M. Fournier, H. Mal, G. Leseche, and R. Porcher Determinants of the Survival Benefit of Lung Transplantation in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. O'Connell, M. E. Campbell, R. M. Goldberg, A. Grothey, J.-F. Seitz, J. K. Benedetti, T. Andre, D. G. Haller, and D. J. Sargent Survival Following Recurrence in Stage II and III Colon Cancer: Findings From the ACCENT Data Set J. Clin. Oncol., May 10, 2008; 26(14): 2336 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pilote MD PhD, M. Abrahamowicz PhD, M. Eisenberg MD MPH, K. Humphries DSc, H. Behlouli MSc PhD, and J. V. Tu MD PhD Effect of different angiotensin-converting-enzyme inhibitors on mortality among elderly patients with congestive heart failure Can. Med. Assoc. J., May 6, 2008; 178(10): 1303 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Wellenius, K. J. Mukamal, A. Kulshreshtha, S. Asonganyi, and M. A. Mittleman Depressive Symptoms and the Risk of Atherosclerotic Progression Among Patients With Coronary Artery Bypass Grafts Circulation, May 6, 2008; 117(18): 2313 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J Brunner, A. Mosdol, D. R Witte, P. Martikainen, M. Stafford, M. J Shipley, and M. G Marmot Dietary patterns and 15-y risks of major coronary events, diabetes, and mortality Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1414 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Torabi, J. G.F. Cleland, N. K. Khan, P. H. Loh, A. L. Clark, F. Alamgir, J. L. Caplin, A. S. Rigby, and K. Goode The timing of development and subsequent clinical course of heart failure after a myocardial infarction Eur. Heart J., April 1, 2008; 29(7): 859 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, G. Tomlinson, G. Naglie, W. L Cook, and S. V. Jassal Geriatric comorbidities, such as falls, confer an independent mortality risk to elderly dialysis patients Nephrol. Dial. Transplant., April 1, 2008; 23(4): 1396 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kathiresan, O. Melander, D. Anevski, C. Guiducci, N. P. Burtt, C. Roos, J. N. Hirschhorn, G. Berglund, B. Hedblad, L. Groop, et al. Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events N. Engl. J. Med., March 20, 2008; 358(12): 1240 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Di Costanzo, S. Gasperoni, L. Manzione, G. Bisagni, R. Labianca, S. Bravi, E. Cortesi, P. Carlini, R. Bracci, S. Tomao, et al. Adjuvant Chemotherapy in Completely Resected Gastric Cancer: A Randomized Phase III Trial Conducted by GOIRC J Natl Cancer Inst, March 19, 2008; 100(6): 388 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C.U. Cheang, D. Voduc, C. Bajdik, S. Leung, S. McKinney, S. K. Chia, C. M. Perou, and T. O. Nielsen Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype Clin. Cancer Res., March 1, 2008; 14(5): 1368 - 1376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Fife, T.-C. Meng, D. G. Ferris, and P. Liu Effect of Resiquimod 0.01% Gel on Lesion Healing and Viral Shedding When Applied to Genital Herpes Lesions Antimicrob. Agents Chemother., February 1, 2008; 52(2): 477 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tribouilloy, D. Rusinaru, H. Mahjoub, V. Souliere, F. Levy, M. Peltier, M. Slama, and Z. Massy Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study Eur. Heart J., February 1, 2008; 29(3): 339 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. van der Steeg, P. Steures, M. J.C. Eijkemans, J. D. F. Habbema, P. G.A. Hompes, J. M. Burggraaff, G. J. E. Oosterhuis, P. M.M. Bossuyt, F. van der Veen, and B. W.J. Mol Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women Hum. Reprod., February 1, 2008; 23(2): 324 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hoster, M. Dreyling, W. Klapper, C. Gisselbrecht, A. van Hoof, H. C. Kluin-Nelemans, M. Pfreundschuh, M. Reiser, B. Metzner, H. Einsele, et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma Blood, January 15, 2008; 111(2): 558 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Miller, M. Wang, J. Gralow, M. Dickler, M. Cobleigh, E. A. Perez, T. Shenkier, D. Cella, and N. E. Davidson Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer N. Engl. J. Med., December 27, 2007; 357(26): 2666 - 2676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Liou, F. R. Adler, D. R. Cox, and B. C. Cahill Lung Transplantation and Survival in Children with Cystic Fibrosis N. Engl. J. Med., November 22, 2007; 357(21): 2143 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Hanrahan, A. M. Gonzalez-Angulo, S. H. Giordano, R. Rouzier, K. R. Broglio, G. N. Hortobagyi, and V. Valero Overall Survival and Cause-Specific Mortality of Patients With Stage T1a,bN0M0 Breast Carcinoma J. Clin. Oncol., November 1, 2007; 25(31): 4952 - 4960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-L. Chien, H.-C. Hsu, T.-C. Su, M.-F. Chen, Y.-T. Lee, and F. B. Hu Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese J. Lipid Res., November 1, 2007; 48(11): 2499 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mathew, P. F. Thall, C. D. Bucana, W. K. Oh, M. J. Morris, D. M. Jones, M. M. Johnson, S. Wen, L. C. Pagliaro, N. M. Tannir, et al. Platelet-Derived Growth Factor Receptor Inhibition and Chemotherapy for Castration-Resistant Prostate Cancer with Bone Metastases Clin. Cancer Res., October 1, 2007; 13(19): 5816 - 5824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Pinder, Z. Duan, J. S. Goodwin, G. N. Hortobagyi, and S. H. Giordano Congestive Heart Failure in Older Women Treated With Adjuvant Anthracycline Chemotherapy for Breast Cancer J. Clin. Oncol., September 1, 2007; 25(25): 3808 - 3815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lipton, R. J. Cook, P. Major, M. R. Smith, and R. E. Coleman Zoledronic Acid and Survival in Breast Cancer Patients with Bone Metastases and Elevated Markers of Osteoclast Activity Oncologist, September 1, 2007; 12(9): 1035 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sjostrom, K. Narbro, C. D. Sjostrom, K. Karason, B. Larsson, H. Wedel, T. Lystig, M. Sullivan, C. Bouchard, B. Carlsson, et al. Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects N. Engl. J. Med., August 23, 2007; 357(8): 741 - 752. [Abstract] [Full Text] [PDF]
|
|