Skip Navigation

Biometrika 1994 81(2):259-270; doi:10.1093/biomet/81.2.259
© 1994 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by DARROCH, J. N.
Right arrow Articles by BORKENT, M.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Synergism, attributable risk and interaction for two binary exposure factors

J. N. DARROCH and M. BORKENT

Discipline of Statistical Science, Flinders University of South Australia GPO Box 2100, Adelaide, South Australia 5001, Australia

The concept of attributable risk for one binary exposure factor is reviewed and then extended to two factors. Synergistic, parallel and two other kinds of joint action between the two factors are defined, and it is shown how to estimate the amounts of action of each kind. A proposal of Hamilton (1979) is reviewed. The additive and multiplicative models of no interaction are freshly interpreted in terms of synergistic and parallel action.

Key Words: Additive interaction • Antagonism • Attributable risk • Disease hit • Health hit • Maximum entropy • Multiplicative interaction • Multistage model • Parallel action • Synergism


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BiometrikaHome page
T. J. Vanderweele and J. M. Robins
Empirical and counterfactual conditions for sufficient cause interactions
Biometrika, March 1, 2008; 95(1): 49 - 61.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.