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Biometrika 1988 75(4):723-729; doi:10.1093/biomet/75.4.723
© 1988 by Biometrika Trust
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Exact confidence intervals following a group sequential trial: A comparison of methods

GARY L. ROSNER and ANASTASIOS A. TSIATIS

Department of Epidemiology and Public Health, Yale School of Medicine New Haven, Connecticut 06510, U.S.A.
Department of Biostatistics, Harvard School of Public Health Boston, Massachusetts 02115, U.S.A.

With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.

Key Words: Coverage probability • Repeated significance tests • Score function


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