Skip Navigation

Biometrika 1987 74(1):149-154; doi:10.1093/biomet/74.1.149
© 1987 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by KIM, K.
Right arrow Articles by DEMETS, D. L.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Design and analysis of group sequential tests based on the type I error spending rate function

KYUNGMANN KIM and DAVID L. DEMETS

Biostatistics Center, University of Wisconsin Madison, Wisconsin 53706, U.S.A.

Lan & DeMets (1983) devised a method of constructing discrete group sequential boundaries by using the type I error spending rate function. It is extended so as to generate asymmetric as well as symmetric two-sided boundaries for clinical trials. The design aspect of this procedure is explored in terms of the maximum sample size needed to achieve a desired level of power and the expected stopping times under both null and alternative hypotheses. Finally, these properties are employed in search of appropriate type I error spending rate functions for differing situations.

Key Words: Brownian motion process • Expected stopping time • First exit time • Maximum sample size • Survival study


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin TrialsHome page
R. J Lewis, A. M Lipsky, and D. A Berry
Bayesian decision-theoretic group sequential clinical trial design based on a quadratic loss function: a frequentist evaluation
Clinical Trials, February 1, 2007; 4(1): 5 - 14.
[Abstract] [PDF]

Home page
 Clin TrialsHome page
D. K Brandt, J. A Hind, J. Robbins, A. S Lindblad, G. Gensler, G. Gill, H. Baum, D. Lilienfeld, J. A Logemann, and Communication Sciences and Disorders Clinical Tria
Challenges in the design and conduct of a randomized study of two interventions for liquid aspiration
Clinical Trials, October 1, 2006; 3(5): 457 - 468.
[Abstract] [PDF]

Home page
 NEJMHome page
A. Kadish, A. Dyer, J. P. Daubert, R. Quigg, N.A. M. Estes, K. P. Anderson, H. Calkins, D. Hoch, J. Goldberger, A. Shalaby, et al.
Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy
N. Engl. J. Med., May 20, 2004; 350(21): 2151 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. B. Duggan, G. R. Petroni, J. L. Johnson, J. H. Glick, R. I. Fisher, J. M. Connors, G. P. Canellos, and B. A. Peterson
Randomized Comparison of ABVD and MOPP/ABV Hybrid for the Treatment of Advanced Hodgkin's Disease: Report of an Intergroup Trial
J. Clin. Oncol., February 15, 2003; 21(4): 607 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
B. Spiessens, E. Lesaffre, G. Verbeke, K. Kim, and D. L DeMets
An overview of group sequential methods in longitudinal clinical trials
Statistical Methods in Medical Research, October 1, 2000; 9(5): 497 - 515.
[Abstract] [PDF]

Home page
 NEJMHome page
D. Birnkrant, J. M. Jacobson, J. S. Greenspan, and J. Spritzler
Thalidomide for Aphthous Ulcers in HIV Infection
N. Engl. J. Med., October 9, 1997; 337(15): 1086 - 1087.
[Full Text]

Home page
 NEJMHome page
J. M. Jacobson, J. S. Greenspan, J. Spritzler, N. Ketter, J. L. Fahey, J. B. Jackson, L. Fox, M. Chernoff, A. W. Wu, L. A. MacPhail, et al.
Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection
N. Engl. J. Med., May 22, 1997; 336(21): 1487 - 1493.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.