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Biometrika 1986 73(3):707-715; doi:10.1093/biomet/73.3.707
© 1986 by Biometrika Trust
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Analysis of repeated measures designs with changing covariates in clinical trials

H. I. PATEL

AT &T Bell Laboratories Marray Hill, New Jersey 07974, U.S.A.

A multivariate model is proposed for analysing repeated measures designs with changing or within-subject covariates. Under the assumption of multivariate normality the likelihood ratio tests are derived for testing certain linear hypotheses. Some special designs are discussed and a numerical example is given to illustrate the method for analysing a two-period crossover design.

Key Words: Changing covariate • Likelihood ratio test • Repeated measures design • Two-period crossover design


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