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Biometrika 1986 73(1):13-22; doi:10.1093/biomet/73.1.13
© 1986 by Biometrika Trust
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Longitudinal data analysis using generalized linear models

KUNG-YEE LIANG and SCOTT L. ZEGER

Department of Biostatistics, Johns Hopkins University Baltimore, Maryland 21205, U.S.A.

This paper proposes an extension of generalized linear models to the analysis of longitudinal data. We introduce a class of estimating equations that give consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence. The estimating equations are derived without specifying the joint distribution of a subject's observations yet they reduce to the score equations for niultivariate Gaussian outcomes. Asymptotic theory is presented for the general class of estimators. Specific cases in which we assume independence, m-dependence and exchangeable correlation structures from each subject are discussed. Efficiency of the pioposecl estimators in two simple situations is considered. The approach is closely related to quasi-likelihood.

Key Words: Estimating equation • Generalized linear model • Longitudinal data • Quasi-likelihood • Repeated measures


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Perception of Robot Passability With Direct Line of Sight and Teleoperation
Human Factors: The Journal of the Human Factors and Ergonomics Society, August 1, 2009; 51(4): 557 - 570.
[Abstract] [PDF]


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Int J EpidemiolHome page
A. N. Turner, W. C Miller, N. S Padian, J. S Kaufman, F. M Behets, T. Chipato, F. A Mmiro, R. A Salata, and C. S Morrison
Unprotected sex following HIV testing among women in Uganda and Zimbabwe: short- and long-term comparisons with pre-test behaviour
Int. J. Epidemiol., August 1, 2009; 38(4): 997 - 1007.
[Abstract] [Full Text] [PDF]


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NEJMHome page
D. Sur, R. L. Ochiai, S. K. Bhattacharya, N. K. Ganguly, M. Ali, B. Manna, S. Dutta, A. Donner, S. Kanungo, J. K. Park, et al.
A Cluster-Randomized Effectiveness Trial of Vi Typhoid Vaccine in India
N. Engl. J. Med., July 23, 2009; 361(4): 335 - 344.
[Abstract] [Full Text] [PDF]


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Am J EpidemiolHome page
E. Oken, K. P. Kleinman, M. B. Belfort, J. K. Hammitt, and M. W. Gillman
Associations of Gestational Weight Gain With Short- and Longer-term Maternal and Child Health Outcomes
Am. J. Epidemiol., July 15, 2009; 170(2): 173 - 180.
[Abstract] [Full Text] [PDF]


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The GerontologistHome page
M. Baumgarten, D. Margolis, D. Orwig, W. Hawkes, S. Rich, P. Langenberg, M. Shardell, M. H. Palmer, P. McArdle, R. Sterling, et al.
Use of Pressure-Redistributing Support Surfaces Among Elderly Hip Fracture Patients Across the Continuum of Care: Adherence to Pressure Ulcer Prevention Guidelines
Gerontologist, July 8, 2009; (2009) gnp101v1.
[Abstract] [Full Text] [PDF]


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Research on Social Work PracticeHome page
J. A. Hall, M. S. Vaughan Sarrazin, D. L. Huber, T. Vaughn, R. I. Block, A. R. Reedy, and MiJin Jang
Iowa Case Management for Rural Drug Abuse
Research on Social Work Practice, July 1, 2009; 19(4): 407 - 422.
[Abstract] [PDF]


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JCOHome page
L. Nekhlyudov, L. A. Habel, N. S. Achacoso, I. Jung, R. Haque, L. C. Collins, S. J. Schnitt, C. P. Quesenberry Jr, and S. W. Fletcher
Adherence to Long-Term Surveillance Mammography Among Women With Ductal Carcinoma In Situ Treated With Breast-Conserving Surgery
J. Clin. Oncol., July 1, 2009; 27(19): 3211 - 3216.
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RadiologyHome page
P. R. Bakic, A.-K. Carton, D. Kontos, C. Zhang, A. B. Troxel, and A. D. A. Maidment
Breast Percent Density: Estimation on Digital Mammograms and Central Tomosynthesis Projections1
Radiology, July 1, 2009; 252(1): 40 - 49.
[Abstract] [Full Text] [PDF]


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BiostatisticsHome page
J. Hu and F. Hu
Estimating equation-based causality analysis with application to microarray time series data
Biostat., July 1, 2009; 10(3): 468 - 480.
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BiostatisticsHome page
D. H. Y. Leung, Y.-G. Wang, and M. Zhu
Efficient parameter estimation in longitudinal data analysis using a hybrid GEE method
Biostat., July 1, 2009; 10(3): 436 - 445.
[Abstract] [Full Text] [PDF]


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ANN OCCUP HYGHome page
C.-C. Chen, C.-L. Chuang, K.-Y. Wu, and C.-C. Chan
Sampling Strategies for Occupational Exposure Assessment under Generalized Linear Model
Ann. Hyg., July 1, 2009; 53(5): 509 - 521.
[Abstract] [Full Text] [PDF]


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JNCI J Natl Cancer InstHome page
G. T. Armstrong, Q. Liu, Y. Yasui, S. Huang, K. K. Ness, W. Leisenring, M. M. Hudson, S. S. Donaldson, A. A. King, M. Stovall, et al.
Long-Term Outcomes Among Adult Survivors of Childhood Central Nervous System Malignancies in the Childhood Cancer Survivor Study
J Natl Cancer Inst, July 1, 2009; 101(13): 946 - 958.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
D. M. Shahian, S. M. O'Brien, G. Filardo, V. A. Ferraris, C. K. Haan, J. B. Rich, S.-L. T. Normand, E. R. DeLong, C. M. Shewan, R. S. Dokholyan, et al.
The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1--coronary artery bypass grafting surgery.
Ann. Thorac. Surg., July 1, 2009; 88(1 Suppl): S2 - 22.
[Abstract] [Full Text] [PDF]


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Br J OphthalmolHome page
S J Isenberg, E Sanchez, and K C Zafran
The effect of masking manuscripts for the peer-review process of an ophthalmic journal
Br J Ophthalmol, July 1, 2009; 93(7): 881 - 884.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
S. M. O'Brien, D. M. Shahian, G. Filardo, V. A. Ferraris, C. K. Haan, J. B. Rich, S.-L. T. Normand, E. R. DeLong, C. M. Shewan, R. S. Dokholyan, et al.
The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery.
Ann. Thorac. Surg., July 1, 2009; 88(1 Suppl): S23 - S42.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
D. M. Shahian, S. M. O'Brien, G. Filardo, V. A. Ferraris, C. K. Haan, J. B. Rich, S.-L. T. Normand, E. R. DeLong, C. M. Shewan, R. S. Dokholyan, et al.
The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 3--valve plus coronary artery bypass grafting surgery.
Ann. Thorac. Surg., July 1, 2009; 88(1 Suppl): S43 - S62.
[Abstract] [Full Text] [PDF]



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