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Biometrika 1985 72(2):471-472; doi:10.1093/biomet/72.2.471
© 1985 by Biometrika Trust
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MISCELLANEA

Propriety of the Mantel - Haenszel variance for the log rank test

NATHAN MANTEL

Department of Mathematics, Statistics and Computer Science, The American University Bethesda, Maryland 20814, U.S.A

A challenge by Brown (1984) of the Mantel-Haenszel variance for the log rank test is dismissed as due to the nonasymptotic situation considered by Brown. Where the censoring mechanism in a time-to-response study could be influenced by treatment, the permutational variance is inappropriate and the Mantel-Haenszel hypergeometric variance must be used. If treatment is known or postulated to have no effect on the censoring mechanism, then use of the Mantel-Haenszel variance removes as a source of variation the chance difference in censoring that might occur.

Key Words: Comparison of survival curves • Conditional experiment • Mantel-Haenszel test • Random censorship • Right censoring • Treatment-dependent censorship


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