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Biometrika 1985 72(2):468-470; doi:10.1093/biomet/72.2.468
© 1985 by Biometrika Trust
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MISCELLANEA

Testing for interaction in multiply-matched case-control studies

JOHN J. GART

Mathematical Statistics and Applied Mathematics Section, Biostatistics Branch, National Cancer Institute Bethesda, Maryland 20205, U.S.A

The test for homogeneity of the relative risk in multiply-matched case-control studies of Ejigou & McHugh (1984) is shown to be simply derived and understood in terms of the traditional theory of Pearsonian chi-squared tests (Cramer, 1946, Ch. 30). For the doubly-matched case it is equivalent to the usual chi-squared test that an odds ratio in a 2x2 table with fixed marginal totals equals four.

Key Words: Case-control study • Chi-squared test • Contingency table interaction • Odds ratio


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