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Biometrika 1983 70(2):492-495; doi:10.1093/biomet/70.2.492
© 1983 by Biometrika Trust
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MISCELLANEA

A comparison of sequential treatment allocation rules

DEREK ROBINSON

Statistical Laboratory, University of Manchester

An experiment is considered which consists of a series of trials, where at each trial one of two treatments must be used, the outcome, ‘success’ or ‘failure’, being known immediately; this is often referred to as a ‘two-armed bandit’. It is required to find a rule for choosing a treatment at each trial which meets, as far as possible, two objectives: (a) to maximize the use of the better treatment, and (b) to minimize the probability of wrongly identifying the better treatment at the end of the experiment. A number of such rules are compared using computer simulation and it is found that an easy-to-use rule based on a dynamic allocation index performs well for a wide range of model parameters.

Key Words: Bayes rule • Dynamic allocation index • Multiarmed bandit • Randomized treatment allocation • Sequential medical trial


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