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Biometrika 1983 70(1):41-55; doi:10.1093/biomet/70.1.41
© 1983 by Biometrika Trust
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The central role of the propensity score in observational studies for causal effects

PAUL R. ROSENBAUM and DONALD B. RUBIN

Department of Statistics and Human Oncology, University of Wisconsin Madison Wisconsin, U.S.A.
University of Chicago Chicago, Illinois, U.S.A.

The propensity score is the conditional probability of assignment to a particular treatment given a vector of observed covariates. Both large and small sample theory show that adjustment for the scalar propensity score is sufficient to remove bias due to all observed covariates. Applications include: (i) matched sampling on the univariate propensity score, which is a generalization of discriminant matching, (ii) multivariate adjustment by subclassification on the propensity score where the same subclasses are used to estimate treatment effects for all outcome variables and in all subpopulations, and (iii) visual representation of multivariate covariance adjustment by a two- dimensional plot.

Key Words: Covariance adjustment • Direct adjustment • Discriminant matching • Matched sampling • Nonrandomized study • Standardization • Stratification • Subclassification


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Having One's Cake and Eating It, Too: Combining True Experiments With Regression Discontinuity Designs
Eval Rev, October 1, 2008; 32(5): 415 - 434.
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Eval RevHome page
L. A. Yurek, J. Vasey, and D. Sullivan Havens
The Use of Self-Generated Identification Codes in Longitudinal Research
Eval Rev, October 1, 2008; 32(5): 435 - 452.
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J Am Coll Cardiol IntvHome page
D.-W. Park, S.-C. Yun, S.-W. Lee, Y.-H. Kim, C. W. Lee, M.-K. Hong, S.-S. Cheong, J.-J. Kim, S.-W. Park, and S.-J. Park
Stent Thrombosis, Clinical Events, and Influence of Prolonged Clopidogrel Use After Placement of Drug-Eluting Stent: Data From an Observational Cohort Study of Drug-Eluting Versus Bare-Metal Stents
J. Am. Coll. Cardiol. Intv., October 1, 2008; 1(5): 494 - 503.
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J. Neurol. Neurosurg. PsychiatryHome page
A Fabbri, F Servadei, G Marchesini, S C Stein, and A Vandelli
Observational approach to subjects with mild-to-moderate head injury and initial non-neurosurgical lesions
J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1180 - 1185.
[Abstract] [Full Text] [PDF]


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Br. J. PsychiatryHome page
I. Colman, T. J. Croudace, M. E. J. Wadsworth, D. Kuh, and P. B. Jones
Psychiatric outcomes 10 years after treatment with antidepressants or anxiolytics
The British Journal of Psychiatry, October 1, 2008; 193(4): 327 - 331.
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Int J EpidemiolHome page
E. P Martens, W. R Pestman, A. de Boer, S. V Belitser, and O. H Klungel
Systematic differences in treatment effect estimates between propensity score methods and logistic regression
Int. J. Epidemiol., October 1, 2008; 37(5): 1142 - 1147.
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BloodHome page
T. M. Habermann, S. S. Wang, M. J. Maurer, L. M. Morton, C. F. Lynch, S. M. Ansell, P. Hartge, R. K. Severson, N. Rothman, S. Davis, et al.
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era
Blood, October 1, 2008; 112(7): 2694 - 2702.
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CirculationHome page
J. F. Sabik III, A. Stockins, E. R. Nowicki, E. H. Blackstone, P. L. Houghtaling, B. W. Lytle, and F. D. Loop
Does Location of the Second Internal Thoracic Artery Graft Influence Outcome of Coronary Artery Bypass Grafting?
Circulation, September 30, 2008; 118(14_suppl_1): S210 - S215.
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ScienceHome page
C. Costello, S. D. Gaines, and J. Lynham
Can Catch Shares Prevent Fisheries Collapse?
Science, September 19, 2008; 321(5896): 1678 - 1681.
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Am J EpidemiolHome page
D. P. Do and B. K. Finch
The Link between Neighborhood Poverty and Health: Context or Composition?
Am. J. Epidemiol., September 15, 2008; 168(6): 611 - 619.
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Am J EpidemiolHome page
V. S. Harder, E. A. Stuart, and J. C. Anthony
Adolescent Cannabis Problems and Young Adult Depression: Male-Female Stratified Propensity Score Analyses
Am. J. Epidemiol., September 15, 2008; 168(6): 592 - 601.
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JNCI J Natl Cancer InstHome page
J. B. Christian, K. L. Lapane, A. L. Hume, C. B. Eaton, and M. A. Weinstock
Association of ACE Inhibitors and Angiotensin Receptor Blockers with Keratinocyte Cancer Prevention in the Randomized VATTC Trial
J Natl Cancer Inst, September 3, 2008; 100(17): 1223 - 1232.
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Party PoliticsHome page
D. Cutts, S. Childs, and E. Fieldhouse
`This is What Happens When You Don't Listen': All-Women Shortlists at the 2005 General Election
Party Politics, September 1, 2008; 14(5): 575 - 595.
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Circ Cardiovasc Qual OutcomesHome page
P. C. Austin
Primer on Statistical Interpretation or Methods Report Card on Propensity-Score Matching in the Cardiology Literature From 2004 to 2006: A Systematic Review
Circ Cardiovasc Qual Outcomes, September 1, 2008; 1(1): 62 - 67.
[Abstract] [Full Text] [PDF]



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