Skip Navigation

Biometrika 1982 69(1):61-67; doi:10.1093/biomet/69.1.61
© 1982 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by ATKINSON, A. C.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Optimum biased coin designs for sequential clinical trials with prognostic factors

A. C. ATKINSON

Department of Mathematics, Imperial College London

The theory of DA-optimum design of experiments is used to provide designs of the biased coin type for sequential clinical trials in the presence, or absence, of prognostic factors. The designs avoid many arbitrary features of earlier schemes.

Key Words: Balance for prognostic factors • Biased coin design • DA-optimum experimental design • Sequential clinical trial


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
M. J. MULLER, A. SCHEURICH, H. WETZEL, A. SZEGEDI, and M. HAUTZINGER
SEQUENTIALLY ADJUSTED RANDOMIZATION TO FORCE BALANCE IN CONTROLLED TRIALS WITH UNKNOWN PREVALENCE OF COVARIATES: APPLICATION TO ALCOHOLISM RESEARCH
Alcohol Alcohol., March 1, 2005; 40(2): 124 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
A. Biswas
Adaptive designs for binary treatment responses in phase III clinical trials: controversies and progress
Statistical Methods in Medical Research, October 1, 2001; 10(5): 353 - 364.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.