Skip Navigation

Biometrika 1975 62(3):679-690; doi:10.1093/biomet/62.3.679
© 1975 by Biometrika Trust
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by TARONE, R. E.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Tests for trend in life table analysis

ROBERT E. TARONE

National Cancer Institute Bethesda, Maryland

Using the regression model proposed by Cox (1972) a test for monotone trend in hazard functions is derived for use, for example, in chemical carcinogenesis experiments in which a chemical is administered at increasing dose levels. It is demonstrated that under the null hypothesis of no dose-response relationship the test statistic is distributed asymptotically as chi-squared with one degree of freedom. An exact test for trend is proposed which is valid when censorship is random and equal.

Key Words: Hazard function • Life table • Log rank teat • Monte Carlo simulation • Random censorship model


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
K. Reynolds, D. Gu, P. Muntner, J. W. Kusek, J. Chen, X. Wu, X. Duan, C.-S. Chen, M. J. Klag, P. K. Whelton, et al.
A Population-Based, Prospective Study of Blood Pressure and Risk for End-Stage Renal Disease in China
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1928 - 1935.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
D. L. Shuey, C. Woodland, C. Tremblay, R. Gregson, and R. J. Gerson
Oxymorphone Hydrochloride, a Potent Opioid Analgesic, Is Not Carcinogenic in Rats or Mice
Toxicol. Sci., March 1, 2007; 96(1): 162 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
G. E. Kissling, N. J. Bernheim, W. E. Hawkins, M. J. Wolfe, M. P. Jokinen, C. S. Smith, R. A. Herbert, and G. A. Boorman
The Utility of the Guppy (Poecilia reticulata) and Medaka (Oryzias latipes) in Evaluation of Chemicals for Carcinogenicity
Toxicol. Sci., July 1, 2006; 92(1): 143 - 156.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
V. Pagliarulo, D. Hawes, F. H. Brands, S. Groshen, J. Cai, J. P. Stein, G. Lieskovsky, D. G. Skinner, and R. J. Cote
Detection of Occult Lymph Node Metastases in Locally Advanced Node-Negative Prostate Cancer
J. Clin. Oncol., June 20, 2006; 24(18): 2735 - 2742.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. M. Doi, J. R. Hailey, M. Hejtmancik, J. D. Toft II, M. Vallant, and R. S. Chhabra
Topical Application of Representative Multifunctional Acrylates Produced Proliferative and Inflammatory Lesions in F344/N Rats and B6C3F1 Mice, and Squamous Cell Neoplasms in Tg.AC Mice
Toxicol Pathol, October 1, 2005; 33(6): 631 - 640.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. E. Wyde, A. P. J. M. Braen, M. Hejtmancik, J. D. Johnson, J. D. Toft, J. C. Blake, S. D. Cooper, J. Mahler, M. Vallant, J. R. Bucher, et al.
Oral and Dermal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Cutaneous Papillomas and Squamous Cell Carcinomas in Female Hemizygous Tg.AC Transgenic Mice
Toxicol. Sci., November 1, 2004; 82(1): 34 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
J. L. Mauderly, A. P. Gigliotti, E. B. Barr, W. E. Bechtold, S. A. Belinsky, F. F. Hahn, C. A. Hobbs, T. H. March, S. K. Seilkop, and G. L. Finch
Chronic Inhalation Exposure to Mainstream Cigarette Smoke Increases Lung and Nasal Tumor Incidence in Rats
Toxicol. Sci., October 1, 2004; 81(2): 280 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. K. Haseman, E. Ney, A. Nyska, and G. N. Rao
Effect of Diet and Animal Care/Housing Protocols on Body Weight, Survival, Tumor Incidences, and Nephropathy Severity of F344 Rats in Chronic Studies
Toxicol Pathol, October 1, 2003; 31(6): 674 - 681.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
L. A. Bazzano, J. He, L. G. Ogden, C. M. Loria, and P. K. Whelton
Dietary Fiber Intake and Reduced Risk of Coronary Heart Disease in US Men and Women: The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study
Arch Intern Med, September 8, 2003; 163(16): 1897 - 1904.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. B. Ress, B. J. Chou, R. A. Renne, J. A. Dill, R. A. Miller, J. H. Roycroft, J. R. Hailey, J. K. Haseman, and J. R. Bucher
Carcinogenicity of Inhaled Vanadium Pentoxide in F344/N Rats and B6C3F1 Mice
Toxicol. Sci., August 1, 2003; 74(2): 287 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. B. Ress, J. R. Hailey, R. R. Maronpot, J. R. Bucher, G. S. Travlos, J. K. Haseman, D. P. Orzech, J. D. Johnson, and M. R. Hejtmancik
Toxicology and Carcinogenesis Studies of Microencapsulated Citral in Rats and Mice
Toxicol. Sci., February 1, 2003; 71(2): 198 - 206.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. E. Wagner, J. N. Barker, T. E. DeFor, K. S. Baker, B. R. Blazar, C. Eide, A. Goldman, J. Kersey, W. Krivit, M. L. MacMillan, et al.
Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
Blood, August 13, 2002; 100(5): 1611 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. He, L. G. Ogden, L. A. Bazzano, S. Vupputuri, C. Loria, and P. K. Whelton
Dietary Sodium Intake and Incidence of Congestive Heart Failure in Overweight US Men and Women: First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study
Arch Intern Med, July 22, 2002; 162(14): 1619 - 1624.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. A Bazzano, J. He, L. G Ogden, C. M Loria, S. Vupputuri, L. Myers, and P. K Whelton
Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study
Am. J. Clinical Nutrition, July 1, 2002; 76(1): 93 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
B. I. Ghanayem, A. Nyska, J. K. Haseman, and J. R. Bucher
Acrylonitrile Is a Multisite Carcinogen in Male and Female B6C3F1 Mice
Toxicol. Sci., July 1, 2002; 68(1): 59 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
J. R. Herman, L. A. Dethloff, E. J. McGuire, R. F. Parker, K. M. Walsh, A. W. Gough, H. Masuda, and F. A. de la Iglesia
Rodent Carcinogenicity with the Thiazolidinedione Antidiabetic Agent Troglitazone
Toxicol. Sci., July 1, 2002; 68(1): 226 - 236.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. A. Bazzano, J. He, L. G. Ogden, C. Loria, S. Vupputuri, L. Myers, P. K. Whelton, and S. E. Kasner
Dietary Intake of Folate and Risk of Stroke in US Men and Women: NHANES I Epidemiologic Follow-Up Study * Editorial Comment: NHANES I Epidemiologic Follow-Up Study
Stroke, May 1, 2002; 33(5): 1183 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
L. A. Bazzano, J. He, L. G. Ogden, C. Loria, S. Vupputuri, L. Myers, and P. K. Whelton
Legume Consumption and Risk of Coronary Heart Disease in US Men and Women: NHANES I Epidemiologic Follow-up Study
Arch Intern Med, November 26, 2001; 161(21): 2573 - 2578.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
V. N. Anisimov, N. Y. Zavarzina, M. A. Zabezhinski, I. G. Popovich, O. A. Zimina, A. V. Shtylick, A. V. Arutjunyan, T. I. Oparina, V. M. Prokopenko, A. I. Mikhalski, et al.
Melatonin Increases Both Life Span and Tumor Incidence in Female CBA Mice
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2001; 56(7): B311 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. He, L. G. Ogden, L. A. Bazzano, S. Vupputuri, C. Loria, and P. K. Whelton
Risk Factors for Congestive Heart Failure in US Men and Women: NHANES I Epidemiologic Follow-up Study
Arch Intern Med, April 9, 2001; 161(7): 996 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
R. S. Chhabra, R. A. Herbert, J. R. Bucher, G. S. Travlos, J. D. Johnson, and M. R. Hejtmancik
Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone in Rats and Mice
Toxicol. Sci., March 1, 2001; 60(1): 28 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
D. Gulezian, D. Jacobson-Kram, C. B. Mccullough, H. Olson, L. Recio, D. Robinson, R. Storer, R. Tennant, J. M. Ward, and D. A. Neumann
Review Article: Use of Transgenic Animals for Carcinogenicity Testing: Considerations and Implications for Risk Assessment
Toxicol Pathol, May 1, 2000; 28(3): 482 - 499.
[Abstract] [PDF]

Home page
 JAMAHome page
J. He, L. G. Ogden, S. Vupputuri, L. A. Bazzano, C. Loria, and P. K. Whelton
Dietary Sodium Intake and Subsequent Risk of Cardiovascular Disease in Overweight Adults
JAMA, December 1, 1999; 282(21): 2027 - 2034.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
G. A. Boorman, D. L. McCormick, J. C. Findlay, J. R. Hailey, J. R. Gauger, T. R. Johnson, R. M. Kovatch, R. C. Sills, and J. K. Haseman
Chronic Toxicity/Oncogenicity Evaluation of 60 Hz (Power Frequency) Magnetic Fields in F344/N Rats
Toxicol Pathol, May 1, 1999; 27(3): 267 - 278.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
D. L. Mccormick, G. A. Boorman, J. C. Findlay, J. R. Hailey, T. R. Johnson, J. R. Gauger, J. M. Pletcher, R. C. Sills, and J. K. Haseman
Chronic Toxicity/Oncogenicity Evaluation of 60 Hz (Power Frequency) Magnetic Fields in B6C3F1 Mice
Toxicol Pathol, May 1, 1999; 27(3): 279 - 285.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
R. L. Melnick, R. C. Sills, C. J. Portier, J. H. Roycroft, B. J. Chou, S. L. Grumbein, and R. A. Miller
Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose–response with 1,3-butadiene in mice
Carcinogenesis, May 1, 1999; 20(5): 867 - 878.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.