© 1975 by Biometrika Trust
Tests for trend in life table analysis
National Cancer Institute Bethesda, Maryland
Using the regression model proposed by Cox (1972) a test for monotone trend in hazard functions is derived for use, for example, in chemical carcinogenesis experiments in which a chemical is administered at increasing dose levels. It is demonstrated that under the null hypothesis of no dose-response relationship the test statistic is distributed asymptotically as chi-squared with one degree of freedom. An exact test for trend is proposed which is valid when censorship is random and equal.
Key Words: Hazard function • Life table • Log rank teat • Monte Carlo simulation • Random censorship model
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