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Biometrika 1974 61(1):17-30; doi:10.1093/biomet/61.1.17
© 1974 by Biometrika Trust
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Survival analyses in twin studies and matched pair experiments

J. D. HOLT1 and R. L. PRENTICE2

1Department of Mathematics and Statistics, University of Guelph Ontario
2Department of Statistics, University of Waterloo Ontario

Several models for paired failure time data are considered. It is assumed that the effects of certain risk factors or treatments are of primary interest and such effects are written as regression parameters in a proportional hazards model. Techniques based on marginally sufficient statistics are proposed for their estimation. Efficiency comparisons are made among estimates based on the suggested models and special attention is given to the study of bias and efficiency in the presence of censoring. Some comparisons are made between the models and analyses presented here and analyses based on study period survival and a binary logistic model for regression parameters.

Key Words: Censoring • Least squares and maximum likelihood estimates • Logistic model • Marginal likelihood • Matched pair experiment • Proportional hazards model • Survival time • Twin studies


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