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Biometrika 1973 60(1):175-178; doi:10.1093/biomet/60.1.175
© 1973 by Biometrika Trust
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Maximum number of statistically significant associations between risk factors and the frequency of an event in observational studies

L. D. MESHALKIN*

The World Health Organization Geneva

*Now at Moscow State University.

Follow-up studies often record a large number of factors that are suspected of being related to the occurrence of an event. How many of them can one hope tresearch-articleo discover as being statistically significantly associated with this event? The number of such associations depends on the degree of risk they impart, the sample size used, the number of factors considered and their distribution in the population under study. An analysis is given when all factors are dichotomous.

Key Words: Follow-up epidemiological studies • Maximum number of important risk factors • Logistic models • Binary data


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