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Biometrika 1971 58(1):77-81; doi:10.1093/biomet/58.1.77
© 1971 by Biometrika Trust
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Duration of detectible synchrony in a binary branching process

DAVID SANKOFF

Université de Montréal

An index for synchrony is defined, based on the age distribution of a population, which can be evaluated at any time, not only once per cell cycle, and which measures the characteristic of the population most relevant for the biological experimenter. The index is calculated for initially synchronized populations of cells having typical generation time distributions. From this we construct a table showing the useful duration, in number of cell cycles, of an experiment using such a population, as a function of the accuracy of the experimental measurement and the coefficient of variation of the generation time distribution.

Key Words: Synchronous growth • Cell division and proliferation • Branching processes • Age distributions • Generation time distributions


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