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Biometrika 1965 52(1-2):203-223; doi:10.1093/biomet/52.1-2.203
© 1965 by Biometrika Trust
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Artcles

A generalized Wilcoxon test for comparing arbitrarily singly-censored samples*

EDMUND A. GEHAN

Birkbeck College, London and the National Institutes of Health Bethesda

A distribution-free two-sample test is proporesearch-articlesed that is an extension of the Wilcoxon test to samples with arbitrary censoring on the right. The test is conditional on the pattern of observations. The null hypothesis is

H0: F1(t) = F2(t) (t ≤ T) against either

H1: F1(t) <F2 (t ≤ T) or

H2: F1(t) < F2(t) or F1(t) > F2(t) (t ≤ T), where F1, F2 are cumulative distributions (discrete or continuous) of the observations and T is their upper limit. The test is shown to be asymptotically normal and consistent against one-sided alternatives F1(t) < F2(t) (t ≤ T) and against two-sided alternatives where either F1(t) < F2(t) or F2(t) > F2(t) (t≤T). The asymptotic efficiency of the test relative to the efficient parametric test when the distributions are exponential is at least 0.75 and increases with degree of censoring. When H0 is true, the test not seriously affected by real differences in the percentage censored in the two groups. Some comparisons are made for five cases of varying degrees of censoring and tying between probabilities from the exact test and those from the proposed test and these suggest the test is appropriate under certain conditions when the sample size is five in each group. A worked example is presented and some discussion is given to further problems.



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Arch SurgHome page
H. V. Villar, S. E. Jones, G. E. Goodman, T. M. Grogan, G. D. Pond, and S. L. Wangensteen
Posttreatment Laparotomy for Hodgkin's Disease
Arch Surg, November 1, 1983; 118(11): 1272 - 1276.
[Abstract] [PDF]


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Arch Otolaryngol Head Neck SurgHome page
H. Goepfert, M. A. Luna, R. D. Lindberg, and A. K. White
Malignant Salivary Gland Tumors of the Paranasal Sinuses and Nasal Cavity
Arch Otolaryngol Head Neck Surg, October 1, 1983; 109(10): 662 - 668.
[Abstract] [PDF]


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Arch Gen PsychiatryHome page
B. A. Judson, A. Goldstein, and C. E. Inturrisi
Methadyl Acetate (LAAM) in the Treatment of Heroin Addicts: II. Double-blind Comparison of Gradual and Abrupt Detoxification
Arch Gen Psychiatry, August 1, 1983; 40(8): 834 - 840.
[Abstract] [PDF]


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ANN INTERN MEDHome page
S. CARETTE, J. H. KLIPPEL, J. L. DECKER, H. A. AUSTIN, P. H. PLOTZ, A. D. STEINBERG, and J. E. BALOW
Controlled Studies of Oral Immunosuppressive Drugs in Lupus Nephritis: A Long-Term Follow-Up
Ann Intern Med, July 1, 1983; 99(1): 1 - 8.
[Abstract] [PDF]


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Eval RevHome page
A. Solberg
Community Posthospital Follow-Up Services
Eval Rev, January 1, 1983; 7(1): 96 - 109.
[Abstract] [PDF]


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JAMAHome page
M. J. Keating, K. B. McCredie, G. P. Bodey, T. L. Smith, E. Gehan, and E. J Freireich
Improved Prospects for Long-term Survival in Adults With Acute Myelogenous Leukemia
JAMA, November 19, 1982; 248(19): 2481 - 2486.
[Abstract] [PDF]


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JAMAHome page
C. L. Day Jr, M. C. Mihm Jr, A. J. Sober, T. B. Fitzpatrick, R. A. Malt, A. W. Kopf, R. A. Lew, and T. J. Harrist
Skin Lesions Suspected to Be Melanoma Should Be Photographed: Gross Morphological Features of Primary Melanoma Associated With Metastases
JAMA, September 3, 1982; 248(9): 1077 - 1081.
[Abstract] [PDF]


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Arch Intern MedHome page
I. M. Cohen, J. N. Galgiani, D. Potter, and D. A. Ogden
Coccidioidomycosis in Renal Replacement Therapy
Arch Intern Med, March 1, 1982; 142(3): 489 - 494.
[Abstract] [PDF]


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ANN INTERN MEDHome page
K. M. SCHWARTZ, J. D. TURNER, L. T. SHEFFIELD, D. I. ROITMAN, S. KANSAL, S. E. PAPAPIETRO, J. A. MANTLE, C. E. RACKLEY, R. O. RUSSELL Jr., and W. J. ROGERS
Limited Exercise Testing Soon After Myocardial Infarction: Correlation with Early Coronary and Left Ventricular Angiography
Ann Intern Med, June 1, 1981; 94(6): 727 - 734.
[Abstract] [PDF]


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JAMAHome page
M. M. Bortin, R. P. Gale, and A. A. Rimm
Allogeneic Bone Marrow Transplantation for 144 Patients With Severe Aplastic Anemia
JAMA, March 20, 1981; 245(11): 1132 - 1139.
[Abstract] [PDF]


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Arch Intern MedHome page
R. Feld, J. F. Pringle, W. K. Evans, C. W. Keen, I. C. Quirt, J. E. Curtis, M. A. Baker, J. L. Yeoh, G. Deboer, and T. C. Brown
Combined Modality Treatment of Small Cell Carcinoma of the Lung
Arch Intern Med, March 1, 1981; 141(4): 469 - 473.
[Abstract] [PDF]


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Arch Otolaryngol Head Neck SurgHome page
D. J. H. Wagenfeld, A. R. Harwood, D. P. Bryce, A. W. P. van Nostrand, and G. de Boer
Second Primary Respiratory Tract Malignant Neoplasms in Supraglottic Carcinoma
Arch Otolaryngol Head Neck Surg, March 1, 1981; 107(3): 135 - 137.
[Abstract] [PDF]


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L. R. Zacharski, W. G. Henderson, F. R. Rickles, W. B. Forman, C. J. Cornell Jr, R. J. Forcier, R. Edwards, E. Headley, S.-H. Kim, J. R. O'Donnell, et al.
Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung: Veterans Administration Study No. 75
JAMA, February 27, 1981; 245(8): 831 - 835.
[Abstract] [PDF]


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B.-S. Yap, H.-Y. Yap, H. A. Fritsche, G. Blumenschein, and G. P. Bodey
CSF Carcinoembryonic Antigen in Meningeal Carcinomatosis From Breast Cancer
JAMA, October 3, 1980; 244(14): 1601 - 1603.
[Abstract] [PDF]


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JAMAHome page
J. A. Caprini, M. A. Oviedo, M. P. Cunningham, E. Cohen, R. S. Trueheart, J. D. Khandekar, and E. F. Scanlon
Adjuvant Chemotherapy for Stage II and III Breast Carcinoma
JAMA, July 18, 1980; 244(3): 243 - 246.
[Abstract] [PDF]


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ANN INTERN MEDHome page
D. L. SWEET, H. M. GOLOMB, J. E. ULTMANN, J. B. MILLER, R. S. STEIN, E. P. LESTER, U. MINTZ, J. D. BITRAN, R. A. STREULI, K. DALY, et al.
Cyclophosphamide, Vincristine, Methotrexate with Leucovorin Rescue, and Cytarabine (COMLA) Combination Sequential Chemotherapy for Advanced Diffuse Histiocytic Lymphoma
Ann Intern Med, June 1, 1980; 92(6): 785 - 790.
[Abstract] [PDF]


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R. G. Hoffmann, S. L. Blumlein, A. J. Anderson, J. J. Barboriak, J. A. Walker, and A. A. Rimm
The Probability of Surviving Coronary Bypass Surgery: Five-Year Results From 1,718 Patients
JAMA, April 4, 1980; 243(13): 1341 - 1344.
[Abstract] [PDF]


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ANN INTERN MEDHome page
R. S. STEIN, H. M. GOLOMB, C. H. DIGGS, P. MAUCH, S. HELLMAN, P. H. WIERNIK, J. E. ULTMANN, and D. S. ROSENTHAL
Anatomic Substages of Stage III-A Hodgkin's Disease: A Collaborative Study
Ann Intern Med, February 1, 1980; 92(2_Part_1): 159 - 165.
[Abstract] [PDF]


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ANN INTERN MEDHome page
S. S. LEGHA, A. U. BUZDAR, T. L. SMITH, G. N. HORTOBAGYI, K. D. SWENERTON, G. R. BLUMENSCHEIN, E. A. GEHAN, G. P. BODEY, and E. J. FREIREICH
Complete Remissions in Metastatic Breast Cancer Treated with Combination Drug Therapy
Ann Intern Med, December 1, 1979; 91(6): 847 - 852.
[Abstract] [PDF]


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Arch SurgHome page
S. J. Rossiter, D. C. Miller, E. B. Stinson, P. E. Oyer, B. A. Reitz, and N. E. Shumway
Aortic and Mitral Prosthetic Valve Reoperations: Early and Late Results
Arch Surg, November 1, 1979; 114(11): 1279 - 1283.
[Abstract] [PDF]


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A. U. Buzdar, G. R. Blumenschein, J. U. Gutterman, C. K. Tashima, G. N. Hortobagyi, T. L. Smith, L. T. Campos, W. L. Wheeler, E. M. Hersh, E. J Freireich, et al.
Postoperative Adjuvant Chemotherapy With Fluorouracil, Doxorubicin, Cyclophosphamide, and BCG Vaccine: A Follow-up Report
JAMA, October 5, 1979; 242(14): 1509 - 1513.
[Abstract] [PDF]


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R. T. Eagan, D. S. Childs Jr, D. D. Layton Jr, E. R. Laws Jr, H. F. Bisel, M. A. Holbrook, and T. R. Fleming
Dianhydrogalactitol and Radiation Therapy: Treatment of Supratentorial Glioma
JAMA, May 11, 1979; 241(19): 2046 - 2050.
[Abstract] [PDF]


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ANN INTERN MEDHome page
R. I. FISHER, V. T. DeVITA, S. P. HUBBARD, R. SIMON, and R. C. YOUNG
Prolonged Disease-Free Survival in Hodgkin's Disease with MOPP Reinduction After First Relapse
Ann Intern Med, May 1, 1979; 90(5): 761 - 763.
[Abstract] [PDF]


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M. H. Cohen, P. B. Chretien, D. C. Ihde, B. E. Fossieck Jr, R. Makuch, P. A. Bunn Jr, A. V. Johnston, S. E. Shackney, M. J. Matthews, S. D. Lipson, et al.
Thymosin Fraction V and Intensive Combination Chemotherapy: Prolonging the Survival of Patients With Small-Cell Lung Cancer
JAMA, April 27, 1979; 241(17): 1813 - 1815.
[Abstract] [PDF]


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ANN INTERN MEDHome page
C. S. PORTLOCK and S. A. ROSENBERG
No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types
Ann Intern Med, January 1, 1979; 90(1): 10 - 13.
[Abstract] [PDF]


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ANN INTERN MEDHome page
H. M. GOLOMB, D. CATOVSKY, and D. W. GOLDE
Hairy Cell Leukemia: A Clinical Review Based on 71 Cases
Ann Intern Med, November 1, 1978; 89(5_Part_1): 677 - 683.
[Abstract] [PDF]


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Arch Intern MedHome page
C. A. Coltman Jr, G. P. Bodey, J. S. Hewlett, A. Haut, J. Bickers, S. P. Balcerzak, J. J. Costanzi, E. J. Freireich, K. B. McCredie, C. Groppe, et al.
Chemotherapy of Acute Leukemia: A Comparison of Vincristine, Cytarabine, and Prednisone Alone and in Combination With Cyclophosphamide or Daunorubicin
Arch Intern Med, September 1, 1978; 138(9): 1342 - 1348.
[Abstract] [PDF]


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J. G. Krikorian, J. L. Anderson, C. P. Bieber, I. Penn, and E. B. Stinson
Malignant Neoplasms Following Cardiac Transplantation
JAMA, August 18, 1978; 240(7): 639 - 643.
[Abstract] [PDF]


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Arch Intern MedHome page
F. Cabanillas, J. S. Burke, T. L. Smith, T. E. Moon, J. J. Butler, and V. Rodriguez
Factors Predicting for Response and Survival in Adults With Advanced Non-Hodgkin's Lymphoma
Arch Intern Med, March 1, 1978; 138(3): 413 - 418.
[Abstract] [PDF]



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